Leukemia and Cannabis Oil

In this 2004 scientific study researchers investigated whether THC could induce programmed cell death (also known as apoptosis) in leukemic cell lines. Findings showed that “THC is a potent inducer of apoptosis”. The study goes on to state that “It is important to emphasize that THC was exceptionally efficacious, inducing cell kill as early as 6 hours”.

In 2005 reseachers from the University of South Carolina School of Medicine also looked at how THC causes apoptosis in leukemic cells. The study concluded that, “The intrinsic pathway plays a more critical role in THC-induced apoptosis while the extrinsic pathway may facilitate apoptosis via cross-talk with the intrinsic pathway.”

In 2002 researchers published a study in Blood Journal titled “Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease”. The study asserted that “Culture of primary acute lymphoblastic leukemia cells with THC in vitro reduced cell viability and induced apoptosis. Together, the current data demonstrate that CB2 cannabinoid receptors expressed on malignancies of the immune system may serve as potential targets for the induction of apoptosis. Also, because CB2 agonists lack psychotropic effects, they may serve as novel anticancer agents to selectively target and kill tumors of immune origin.”

In 2003, The Hebrew University Medical Faculty looked into the effects of two non-psychotropic cannabinoids, CBD and CBD-DMH, on leukemia. According to the findings “Two non-psychotropic cannabinoids, cannabidiol (CBD) and cannabidiol-dimethylheptyl (CBD-DMH), induced apoptosis in a human acute myeloid leukemia (AML) HL-60 cell line.”

In 2006 another study was undertaken looking at how CBD affects leukemia. TheUniversity of South Carolina School of Medicine found that “Exposure of leukemia cells to cannabidiol led to cannabinoid receptor 2 (CB2)-mediated reduction in cell viability and induction in apoptosis. Furthermore, cannabidiol treatment led to a significant decrease in tumor burden and an increase in apoptotic tumors in vivo.” The researchers concluded that “Together, the results from this study reveal that cannabidiol, acting through CB2 and regulation of Nox4 and p22phox expression, may be a novel and highly selective treatment for leukemia.”